| Charcot-Marie-Tooth Disease (CMT) (Also known as Hereditary
Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy (PMA)) |
| Onset: |
Childhood to young adulthood. |
| Symptoms: |
Weakness and atrophy of muscles of hands and lower legs, with foot deformities
and some loss of sensation in feet. |
| Progression: |
Slow but variable progression among individuals. Normal life span. |
| Inheritance: |
Autosomal dominant, autosomal recessive, X-linked recessive, X-linked
dominant. |
| Dejerine-Sottas Disease (DS) (Also known
as CMT Type 3 or Progressive Hypertrophic Interstitial Neuropathy)
|
| Onset: |
Early childhood. |
| Symptoms: |
Same as CMT, but more severe.Delayed motor development in childhood. Weakness
and muscle wasting affecting hands and lower legs. Variable loss of sensation
in feet. |
| Progression: |
Severity and progression of disease vary |
| Inheritance: |
Believed to be autosomal dominant. |
| Friedreich's Ataxia (FA) |
| Onset: |
Childhood to adolescence. |
| Symptoms: |
Impairment of limb coordination, with weakness and muscle wasting. |
| Progression: |
Severity and progression of disorder vary. Often associated with diabetes/heart
disease. |
| Inheritance: |
Autosomal recessive. |
